J Biol Chem 270:83938396 Jonigk D, Al-Omari M, Maegel L, Muller M, Izykowski N, Hong J, Hong K, Kim SH, Dorsch M, Mahadeva R, Laenger F, Kreipe H, Braun A, Shahaf G, Lewis EC, Welte T, Dinarello CA, Janciauskiene S (2013) Anti-inflammatory and immunomodulatory properties of alpha1-antitrypsin without inhibition of elastase
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However, in asthma there is increased apoptosis of ciliated epithelial cells leading to epithelial shedding and barrier dysfunction, which increases with disease severity