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Studies of SARS-CoV-2 have also shown that a specific region of the spike protein, known as the receptor binding domain, binds to a receptor called angiotensin-converting enzyme 2 (ACE2)

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[25,59, 60, 61] Tolerization with hCDR1 induced both CD4 + CD25 + and CD8 + CD28 T regs in mice, which suppressed lymphocyte proliferation and autoantibody production

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