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CRH is synthesized in different tissues such as the brainstem, hypothalamus and peripheral organs

Thyroid 20 , 11631173 (2010)

The selection of an antidepressant should be based on a patients unique medical and psychological profile due to the absence of comparative data

A statistically significant difference (p 0.05) difference when the concentration level of control group was compared to all the groups

This activation enhances glutamate release from primary afferent terminals, resulting in increased normal and miniature excitatory postsynaptic currents, and elevates PKC activity, which mediates the phosphorylation of NMDARs (e.g., the GluN1 subunit at Ser896)