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Long-term use of HU reduces mortality rates in both children and adults with SCD and is safe and effective in larger samples of adults and children with SCD [106]

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Initially approved for glycemic control in type 2 diabetes mellitus, their clinical application has expanded into obesity management, cardiovascular risk reduction, and metabolic syndrome modulation

However, elevated temperatures were required to induce quantitative 197m/g Hg 2+ incorporation, as insignificant radiolabeling was observed for reactions conducted at 37 C at high ligand concentration

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