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As MS progresses, CD4 T cells migrate from the periphery into the CNS, where they sustain local inflammation and contribute to neurodegeneration [6, 42]

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Key Expert Findings Herbal cigarette smoke contains carcinogenic PAHs similar to regular cigarette smoke

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This would then suggest that there is a possibility that public health programmes aimed at reducing major depression may have an impact on reducing cigarette smoking, or conversely, public health programmes that help with ceasing smoking could also have indirect effects on helping to reduce major depression (Fergusson, Goodwin, & Horwood, 2003)