Abbreviations AED: antiepileptic drug CNS: central nervous system CoA: coenzyme A CPS: carbamyl phosphate synthase GABA: -aminobutyric acid NAGA: N -acetyl glutamic acid NMDA: N -methyl-D-aspartate PCT: palmityl carnitine transferase VHE: VPA-induced hyperammonaemic encephalopathy VHT: VPA-induced hepatotoxicity VPA: valproic acid
J Histochem Cytochem 61(9):649658 Pyke C, Heller RS, Kirk RK, Orskov C, Reedtz-Runge S, Kaastrup P et al (2014) GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody
Despite this, in this review, we consider evidence from both therapeutic dosing and overdose studies because pre-clinical data suggest everyone would develop liver injury if the dose of paracetamol was sufficiently high for that individual
Therefore, the abnormality of glial cells may damage mitochondrial function, leading to the insufficient energy supply of DA neurons and eventually their death
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