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The convergence of shortened telomeres and unrepaired DNA lesions triggers the senescence-associated secretory phenotype (SASP), through which granulosa cells secrete inflammatory cytokines (IL6, IL8, TNF-), matrix metalloproteinases (MMP1, MMP3), and growth factors (VEGF, FGF2) [185, 200,201,202,203,204]

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Much recent research has focused on biomarkers for SJS/TEN diagnosis and prognostication

Glutathione is a tripeptide built from three amino acids, glutamic acid, cysteine and glycine, and it is regarded as the most important antioxidant made inside our cells

References 1 SungHFerlayJSiegelRLLaversanneMSoerjomataramIJemalAet al