In the absence of amino acids such as cystine, cells promote translation of ATF4 via the general control non-repressor 2 (GCN2) -eukaryotic initiation factor (eIF2a) signaling pathway, which promotes transcription of genes involved in amino acid metabolism and stress response, including SLC7A11, enabling cells to cope with amino acid starvation
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This finding suggests its potential to protect against atherogenesis through NO-related pathways in human umbilical vein endothelial cells [22]
If one of these exit spaces shrinks, it can squeeze the nerve root (the radicular nerve) and cause symptoms in the area served by the nerve