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doi: 10.7326/AITC202007070 63 MeiL.WangJ.HaoY.ZengX.YangY.WuZ.et al

10.3390/ijms222312800 75

In detail, ROS are involved in disturbing antioxidant defenses, the mitochondria, microtubule, ion channels, and biomolecular functions, as well as inducing neuroinflammation, demyelination, and neuronal apoptosis in the process of PIPN ( Pt-induced ROS production easily breaks the balance of endogenous ROS and cellular antioxidant systems to trigger oxidative stress and mitochondrial dysfunction, resulting in the damage or loss of DRG cells containing abundant ROS-sensitive phospholipids ( Regarding ion channels, TRP play a key role in aggravating cold abnormal pain, among which, TRPA1 and transient receptor potential melastatin 8 (TRPM8), as cold-sensitive receptors, could be activated by ROS (Shimizu et al., 2014