Recommended B12 Dosing and Timing During GLP-1 Treatment For patients on semaglutide, typical B12 supplementation recommendations include intramuscular injections of 1,000 mcg monthly, sublingual lozenges at 1,000-2,000 mcg daily, or oral supplements at 2,000 mcg or higher daily
Assessment considerations include: Serum B12 measurement may be considered before initiating Ozempic in high-risk patients (those on metformin, older adults, those with gastrointestinal symptoms, or with restricted diets) Testing for B12 deficiency should be performed in patients on metformin who develop symptoms suggestive of deficiency, as advised by the MHRA Drug Safety Update Consider periodic monitoring in patients with risk factors for B12 deficiency, rather than routine annual testing for all patients Full blood count to identify macrocytic anaemia, which may indicate B12 or folate deficiency Clinical assessment for symptoms of deficiency: fatigue, paraesthesia, cognitive changes, glossitis, or balance problems If B12 levels are borderline or if clinical suspicion remains despite normal serum B12 (measured in pmol/L, with laboratory-specific reference ranges), additional testing may be considered according to local laboratory protocols
The injection involves a small needle into the muscle (usually upper arm or thigh) and feels similar to a flu shot
This is because they create roadblocks that prevent your body from using Vitamin B12 from food or pills
If you have already used or are currently using either of these compounds, it is important to disclose this to your GP or pharmacist without delay
