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doi: 10.3389/fgene.2014.00472 Received 18 November 2014 Accepted 19 December 2014 Published 13 January 2015 Volume 5 - 2014 Edited by Frank John Slack, Beth Israel Deaconess Medical Center Cancer Center/Harvard Medical School, USA Reviewed by Wenyu Luo, University of California, San Francisco/Howard Hughes Medical Institute, USA