glutathione s transferase sigma transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases Upon conjugation of the thiol group of glutathione to the CDNB substrate General reaction catalyzed by glutathione

For covalent drugs, routine monitoring of the warhead reactivity as well as in vivo modification burden should be carried out

as described by Falanga and colleagues, TfR is expressed highly in bone marrow, immune system, and female tissues, moderately in brain, endocrine tissues, lung, gastrointestinal tract, kidney, urinary bladder, male tissues, and skin, and low in muscle tissues, liver, gallbladder, adipose, and soft tissue, aside from serum [21]

Polymyxin derivatives that sensitize Gram-negative bacteria to other antibiotics

M@HMnO2-DP selectively targets tumor cells, delivering DSF to induce cuproptosis independently of external copper sources while disrupting glycolytic pathways and interfering with FeS protein synthesis (Zhu J

Boosts collagen production for youthful, firm skin