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With the purpose of hinder the employ of exogenous and potentially morbigenous albumin and to gain greater specific drug preparation, a MTX albumin-linking prodrug EMc-D-Alaphe-Lys-Lys (gamma-MTX) OH (EMC = 6-maleimide hexpropionic acid) has been developed by Kratz et al

The most common side effects are gastrointestinal, including nausea, diarrhoea, loss of appetite, and mild abdominal discomfort

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Weekly injection protocols offer maximum convenience and minimal injection site management concerns, though they may result in more variable glutathione levels compared to more frequent dosing