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In conclusion, these studies showed an effect of APOE on L-carnitine, its metabolites and acylcarnitines with age in the brain parenchyma and in the cerebrovasculature up to mid-life, which suggest differences in age-related bioenergetic shift between alleles

Knockout of one allele of QPRT recapitulates these effects and increases susceptibility to AKI compared with control mice, which could be prevented by augmenting NAD + metabolism with oral NAM supplementation

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USA 104 , 75947599 (2007)