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However, an unbalanced production of ROS can affect normal physiology by damaging DNA, RNA, proteins, and cellular organelles via lipid peroxidation and may even result in cell death (4, 61)

Studies indicate that ABT-737 effectively induces apoptosis and inhibits senescence in glioblastoma multiforme cells [106]

IGF-1 LR3 (long-acting R3 IGF-1) provides a contrasting approach: direct IGF-1 receptor activation