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Its role has been explored in collagen-related processes, angiogenic signaling, and cellular activity within skin-associated cell types such as fibroblasts and keratinocytes

Thus, according to patent literature the drug-like 8 and 9 exhibit a very high affinity to the Ang IV binding site named the AT4 receptor

Annu Rev Pathol Mech Dis 9(1):147156

Key determinants of their antimicrobial activity include the presence of carboxyl groups and the arrangement of functional subgroups on the benzene ring (340)

Alternatively, this system could also bind tridentately with a single imidazole and two backbone nitrogen atoms or bivalently with two coordinated imidazole nitrogen atoms