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Dosing Protocols Retatrutide (existing protocol) Maintain your current titration: Standard: 0.25mg 0.5mg 1mg 2mg 3mg (weekly increases) Most users stabilize between 1-3mg weekly No need to adjust Reta dose when adding Tesamorelin or MOTS-C Tesamorelin Starting dose: 1mg daily Maintenance dose: 2mg daily Timing: Evening, before bed (aligns with natural GH pulsatility) Injection: SubQ, abdomen or thigh Cycle length: 12 weeks on, 4 weeks off (standard) MOTS-C Option A (daily): 500mcg-1mg daily, morning Option B (pulsed): 5mg 2-3x weekly Timing: Morning preferred (aligns with metabolic activity) Injection: SubQ, any site Cycle length: 8-12 weeks on, 4 weeks off (receptor sensitivity consideration) Daily Schedule Example This schedule keeps compounds separated and aligns with natural physiology (MOTS-C with daytime metabolic activity, Tesamorelin with nighttime GH pulsing)

doi:10.1093/jn/134.3.489 Yeh MY, Burnham EL, Moss M, Brown LA

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