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The McCoy 2013 paper extended this work by introducing N- and C-terminal modifications designed to enhance metabolic stability and hydrophobicity, ultimately producing Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) as an orally active, BBB-permeable analog [2]

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260 More liposome-based biomimetic nanomaterials for drug delivery will be emphasized in section 4.7

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The three most extensively studied peptides in this category are: BPC-157 (Body Protection Compound-157) a stable gastric pentadecapeptide originally identified in gastric juice TB-500 (Thymosin Beta-4) a naturally occurring 43-amino acid actin-regulating peptide GHK-Cu (Copper Tripeptide-1) a copper-binding tripeptide with matrix remodeling properties Each of these peptides operates through distinct molecular mechanisms, yet they share a common theme in their ability to influence cellular processes relevant to tissue repair and structural regeneration