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In support of this approach, prospective studies of smokers in the Shanghai and Singapore cohorts have found that the major nicotine metabolite, cotinine, and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), an established biomarker of the tobacco specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), are significantly associated with lung cancer risk after adjustment for self-reported smoking history
The adenoids can also act as a reservoir for infection
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Acknowledgements The views and opinions expressed in this manuscript are those of the authors only and do not represent the views, official policy, or position of the US Department of Health and Human Services, the US Food and Drug Administration, the National Institute of Health, or any affiliated institutions or agencies