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FIGURE 1 Below are selected examples of the pleiotropic effects of -blockers: - Metabolic effects: -blockers have been linked to metabolic effects, such as weight gain and potential implications in diabetes mellitus (Tomiyama and Yamashina, 2014), while several studies have suggested that vasodilatory -blockers may have beneficial effects on glucose and lipid metabolism (Peixoto et al., 2020