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As summarized in Table 1, key genes involved in bile acid metabolismsuch as FXR, SHP, and ASBTare regulated by specific microbial population like Firmicutes, Lactobacillus , and Bacteroides , influencing bile acid reabsorption and enterohepatic circulation

4.3.3 Hypoxia-inducible factor - 2 (HIF-2) HIF-2 plays a significant role in the progression of OA, particularly in regulating the sensitivity of chondrocytes to ferroptosis