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10.1016/S0960-9822(02)00483-9 Curr

FOXO4-DRI targets a biological process (senescent cell clearance) that produces gradual, systemic effects rather than immediate, obvious changes

Both were 72 week trials in overweight and obese patients with ATTAIN-1 being non-diabetics and ATTAIN-2 being in diabetics

10.1006/abbi.1999.1525 9 ArrigoniO.De TullioM

Dietary supplements: when they may be useful When the diet does not meet nutritional requirements, for example in certain dietary patterns such as vegan diets or when there may be situations affecting nutrient absorption, dietary supplements can be used to complement the diet and help ensure an adequate intake of certain nutrients