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These studies have identified candidate biomarkers and distinct pathophysiologic signatures, which may inform disease classification, risk stratification, and therapeutic targeting [2529]

Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation)

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Compared to Kl-la, Kd-la is more prone to spontaneous lactyl group addition mediated by LGSH [11]

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