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Preclinical studies using T4 (including the RGN-259 ophthalmic clinical trials) have not identified significant adverse events at therapeutic doses

Sigma-Aldrich, St

Endoscopy of the upper gastrointestinal tract can be used to confirm the presence and distribution of disease in the upper gut and to define how severely the mucosa is affected

Given the absence of long-term human trial data, conservative use under clinical supervision is the standard position among practitioners who take the evidence seriously

Like Life Extension, Thorne provides a combination of supplements and at-home health tests (though its hard to beat Life Extensions 230 total Labcorp tests)