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Regulation based on ROS homeostasis holds great potential for maintaining physiological homeostasis and treating diseases

The cell produces free radicals as a byproduct of the chemical events that take place within it

The OHP-induced cytotoxicity in primary Schwann cells and the myelin basic protein expression decreasing indicated that the platinum derivatives also induced Schwann cells mitochondrial dysfunction in vitro [90]

Cells were harvested at defined time points depending on the respective treatment condition for flow cytometry analysis using annexin V and 7-AAD staining

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