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Other mechanisms by which methylene blue may induce neuroprotective effects include facilitating the degradation and clearance of tau proteins, which is a characteristic feature of Alzheimers disease, promoting autophagy, and reducing amyloid plaque accumulation

The field of ALS has advanced significantly over the last decade, with rapid progress in understanding the genetic architecture and the pathophysiological mechanisms of the disease, and in the development of robust, exploitable preclinical model systems

Alsaloum, M

The idea is supported by maintenance of functional GSH/GSSG levels by Sp in BSO and neurotoxin treated cells as compared to untreated ones which showed a significant decline in the antioxidant ratio probably, due to enhanced formation of glutathionequinones 43

They showed gut microbiota to be able to partially sequester dietary Se, limiting its uptake by the host