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Ethanol (alcohol) is broken down by an enzyme called alcohol dehydrogenase (ADH)

Metabolite intermediates or other specific macromolecules leverage porins and outer membrane transporters (TOM) to cross the mitochondrial membrane into the inner mitochondrial space (IMS) or mitochondrial matrix, regulating the TCA cycle and oxidative respiratory chain [20]

Moreover, multiple studies have shown that oral NAD+ is poorly absorbed and does not significantly raise NAD+ levels in the plasma or tissues[9]

Topical application is simple, requires no medical supervision, and integrates easily into daily skincare routines