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What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
Small sample sizes can make drugs look much more or less effective than what they really are
There are two levels available: a 250 mcg level, ideal for people needing maintenance
Research suggests that NNMT inhibition may influence metabolic pathways related to energy expenditure, fat metabolism, and cellular vitality
It is not intended for human consumption, athletic use, veterinary application, clinical diagnosis, or therapeutic purposes
