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Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop

Laboratory studies in cell and animal models of accelerated aging have shown that replenishing NAD+ can restore mitochondrial function and stimulate beneficial cellular recycling processes like mitophagy

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This makes it relevant for forehead lines, crow feet, and other expression-related wrinkles

Some competitive athletes use it to target final stubborn areas during cutting phases, and there's anecdotal support for this but the dramatic results seen in higher-body-fat research subjects won't replicate at 12% BF