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Furthermore, decreased bacterial richness has been linked to high carbohydrate 73 and high-fat/low-protein concentrations 74 , as found in the lean and Western diets, respectively, the latter result only in old-aged rats 74
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Pre-clinical research conducted primarily in animal models has studied its potential roles in supporting the GI environment, gut barrier function, and inflammatory responses in the GI tract
[5] Administering 100,000 IU intramuscularly establishes a high-capacity depot that may correct deficiency more predictably than oral dosing in malabsorption syndromes and maintains adequate circulating vitamin D over two to three months, an approach often referred to as Stoss therapy in endocrinology
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