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Microglial NF-B activation under GSH-depleted conditions creates a pro-inflammatory loop where increased ROS promotes NF-B activation, which upregulates inflammatory cytokines and further stimulates oxidative stress (Liu et al., 2017

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Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease

same separation logic | | Sublingual | Low | None beyond standard care | Limited clinical data on this route | | IV (600-2,400 mg/session) | Low-moderate | Baseline and periodic LFTs | Hepatic conjugation pathway overlap | Patients who are already taking both agents and have experienced no adverse effects can generally continue, provided their prescribing clinician is aware of both