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Concurrently, vitamin B12 deficiency was identified as a significant public health concern, particularly among vulnerable populations such as the elderly and developing embryos, where insufficient B12 levels have been associated with an increased risk of neural tube defects

J Neuropsychiatry Clin Neurosci 37:A6-101

S., Klodt, P

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In high-endemicity settings, mass drug administration once per year or selective drug administration twice per year is recommended, while in moderate endemicity, selective chemotherapy once per year is proposed (286, 287)