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Alcohol increases this effect, which can be a severe problem

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Generally, aberrant cells are recognized by the presence of short peptides generated in the proteasome, transported into the endoplasmic reticulum (ER) by transporters associated with antigen processing (TAP1/2), trimmed by ER aminopeptidases (ERAPs) to modify affinity for Class I molecules, and loaded onto Class I heterodimers comprising a polymorphic heavy -chain and an invariant 2-microglobulin (2M) light chain for presentation at the cell surface 10,11

After centrifugation 300 g , 3 min, cell pellets were washed twice with cold DPBS

Detection methods can identify the peptide and its metabolites in both blood and urine