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Predicted peptide structures from PepStrMod and Iterative Threading ASSEmbly Refinement aid design candidates, but predicted tertiary structures, 153 were successfully modeled, require in vivo testing

Ovarian granulosa cells regulate the accumulation of serotonin in oocytes through the uptake and degradation of serotonin by SERT and monoamine oxidase (MAO), respectively, and granulosa cells form a functional barrier that protects oocytes from exogenous serotonin and may play an important role in oocyte maturation and early embryonic development (Figure 3)