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The main adverse events reported on AIs (anastrozole, letrozole, and exemestane) were decreased libido (27%), arthralgia (24%), mood disorders (12.5%), asthenia (10%), headaches (6%), anxiety (4.5%), and palpitations (3%)

however, some reports focused the attention on a possible relevant role of PPIs in eradicating regimens (Sugimoto and Yamaoka, 2018)

"Our guts are changing all the time, but there are over 1,000 species present in the gut so it's hard to shift in terms of composition," says Freestone