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Mothers in this study were not undernourished, consumed animal protein, and had adequate vitamin B 12 intake during pregnancy and postpartum according to responses given to dietary questionnaires

Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity

generally 2030% higher cost when accounting for supplies

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If a dose is missed, it should be administered as soon as remembered if within five days of the scheduled dose