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The peptide's effects on both dopamine and serotonin systems suggest broad neuromodulatory activity beyond simple tissue healing

Since then, a number of triple agonists have entered clinical development, with one in phase three clinical studies but have yet to reach the market (Capozzi, DiMarchi, Tschp)

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doi: 10.3389/fcell.2025.1639772 Received 02 June 2025 Accepted 27 June 2025 Published 09 July 2025 Volume 13 - 2025 Edited by Jingrui Huang, Central South University, China Reviewed by Xuechun Wang, University of Texas Southwestern Medical Center, United States Gregory J

research shows no additional benefit above 1 mg daily Important: Doses above 1 mg (1,000 mcg) daily showed no additional metabolic benefits in clinical research