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The body produces it in the liver, kidneys, and pancreas

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Further supporting melatonins potential impact on brain insulin, a rat study demonstrated that melatonin, upon binding to its membrane-bound receptors, can initiate intracellular pathways in the brain typically activated by insulin binding to the insulin receptor (e.g., AKT serine phosphorylation) [137]

The Lancet Diabetes & Endocrinology , 12(2), 89-101