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Based on the results of the MTT assay, menthol and ethyl maltol were present at concentrations that would be cytotoxic in 34% (26 of 76) and 40% (66 of 164) of the refill fluids that contained menthol and ethyl maltol, respectively

Respiratory issues: Some studies suggest that dual use may be associated with a higher risk of asthma and chronic obstructive pulmonary disease (COPD) compared to exclusive cigarette use

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