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Procyanidins can reduce inflammation and regulate fat metabolism by reducing the TLR4/NF-B pathway and increasing the AMPK pathway, and they are associated with a decrease in Akkermansia and Bacteroides and an increase in Bifidobacterium , Blautia , Lachnospiraceae , and Subdoligranulum ( Bacteroidetes / Firmicutes ratio, Ruminococcaceae_UCG-014 and Ruminococcaceae_UCG-005 , and decrease Lachnoclostridium (Zhao et al., 2017)

Systems-Level Perspective and Biomarker Potential Analyzing the methionine cycle from a systems biology perspective allows for the identification of metabolic bottlenecks, feedback regulation mechanisms, and potential biomarkers for nutritional status, metabolic disorders, and disease risk

Tatsumi, R., Anderson, J

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