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In rat compressive chronic SCI, we found considerable number of chronically injured axons in the rim of white matter that exhibited aberrant distribution of Kv1.1, Kv1.2, and Caspr along the paranodal and juxtaparanodal regions, an established characteristic of axonal demyelination or dysmyelination (Nashmi et al., 2000

In biochemical and cellular research models, IGF-1 LR3 interacts with the IGF-1 receptor (IGF-1R), initiating intracellular signalling cascades associated with growth factormediated pathways

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rather, its activity is mediated through modulation of multiple intersecting pathways

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