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Improper dosing may reduce effectiveness or increase the risk of adverse effects

Exposure to opioids such as oxycodone results in a greater than six-fold increase in expression in rat liver of glutathione S-transferase A-5, an enzyme that catalyzes conjugation of glutathione to toxic substances, while the expression of the cytochrome enzyme CYP3A2 is decreased seven-fold [24]

doi: 10.3389/fphar.2020.538137 422 LiuMLiWChenYWanXWangJ

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Instead, it is designed to complement healthy nutrition habits and daily wellness routines