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Microbial bile acid metabolites modulate gut ROR+ regulatory T cell homeostasis

In most of our community clinical practices, those with musculoskeletal pain in the context of joint hypermobility are likely to fall under the umbrella of hypermobility spectrum disorders, with hEDS relatively less common

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IFNs bind to cell surface receptors that are associated with janus kinases (JAK), which then phosphorylate intracellular receptor chains, generating docking sites for the signal transducer and activator of transcription (STAT