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This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes

[DOI] [PMC free article] [PubMed] [Google Scholar] Higgins 2009 Higgins JPT, Thompson SG, Spiegelhalter DJ

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