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In view of the socioeconomic and lifestyle factors associated with UPF consumption, greater consideration should be given to multidisciplinary-based interventions when managing patients across a broad range of clinical settings, particularly as limited access to whole foods and constraints on cooking ability may be significant barriers to patients implementing appropriate dietary changes

For instance, prior studies have demonstrated that the activation of LXRs using synthetic agonists such as GW3965 and T0901317 suppresses Th17 cell differentiation in autoimmune diseases [29, 37, 38]

Prebiotic effect of fructo-oligosaccharides on the inner ear of DBA/2 J mice with early-onset progressive hearing loss

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For example, excessive ammonia in the TME can be transformed into L-arginine to promote CD4/CD8 T-cell infiltration and activation, thereby coupling local metabolic reprogramming with site-specific immune enhancement [368]