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Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness

For instance, longitudinal data from the Florey Adelaide Male Aging Study revealed that men with serum testosterone levels below 16 nmol/L (461 ng/dL) had a significantly higher incidence of diabetes [146]

These metabolic alterations were mirrored in transgenic PRKAG2 -mutated mice hearts, which exhibited glycogen accumulation and disrupted lipid metabolism, consistent with findings in PRKAG2 -mutant CMs

12511265, doi:10.1039/c5fo01530h, PMID 26797090

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