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These alterations in the tumor ECM induce an increase in its stiffness, typically evaluated using techniques that either require direct contact with the sample (e.g., atomic force microscopy), or measure the tumor mechanical properties in a contact-free manner (e.g., shear wave elastography, magnetic resonance elastography) (Table 3)

Sci Rep 5 , 10637 (2015)

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So, part of the approach to addressing some of these very complicated patients is working in a partnership with them, because we dont have the answers

Pediatrics 145(4):e20192812