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Within the body, glutathione is present as a reduced and an oxidised form

We further explored the mechanism by which ARID1A loss and c-MET inhibition synergistically inactivate the expression of the antioxidant enzyme GPX4 by inhibiting NRF2 transcription factor, inducing lipid peroxidation and ferroptosis in ARID1A-deficient CRC cells

Necroptosis is a precisely regulated form of programmed necrosis, and its core mechanism hinges on the assembly of the RIPK1/RIPK3 kinase complex and subsequent phosphorylationoligomerisation of MLKL

the minimum sample size was calculated as n = 35.2

Yet, the query persists regarding whether these proteins possess the capacity to impact alternative signal cascades and if metals beyond iron can instigate ferroptosis through distinct molecular pathways