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Upon cellular challenge by electrophiles or ROS, Nrf2 is activated and translocates to the nucleus, where it initiates the transcription of a battery of target genes containing antioxidant response elements or ARE

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The evolutionary history was inferred by using the Maximum Likelihood method based on the JTT (Jones Taylor-Thornton) matrix-based model ( S.cerevisiae and 6 from S.bacillaris FRI751 and PAS13