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Mitochondrial dysfunction and oxidative stress in heart disease

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IGF-1 in the liver can be transferred by insulin-like growth factor binding proteins (IGFBPs) to muscles, where it binds its receptor on the surface of muscular cells, phosphorylates AKT and promotes muscular cell proliferation [14]

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The process of collagen degradation is inhibited by TGF-1, which increases TIMP expression and blocks the actions of MMPs

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Beyond the brain, systemic actors engage in this metabolic ballet through bidirectional axes

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Campione et al

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